laravel artisan 常用命令
2019-03-05sad creeper
php artisan clear-compiled 清除编译后的类文件
php artisan down 使应用程序进入维修模式
php artisan up退出应用程序的维护模式
php artisan env显示当前框架环境
php artisan fresh清除包含框架外的支架
php artisan help显示命令行的帮助
php artisan list列出命令
php artisan migrate运行数据库迁移
php artisan env显示当前框架环境
php artisan optimize为了更好的框架去优化性能
php artisan serve在php开发服务器中服务这个应用
php artisan tinker在应用中交互
php artisan app:name ?设置应用程序命名空间
php artisan auth:clear-resets清除过期的密码重置密钥未使用过
php artisan cache:clear清除应用程序缓存
php artisan cache:table创建一个缓存数据库表的迁移
php artisan config:cache创建一个加载配置的缓存文件
php artisan config:clear删除配置的缓存文件
php artisan db:seed数据库生成模拟数据
php artisan event:generate生成event和listen需要实现配置eventserviceprivoder
php artisan make:command ?创建一个新的命令处理程序类
php artisan make:console ?生成一个Artisan命令
php artisan key:generate设置程序密钥
php artisan make:controller ?生成一个资源控制类
php artisan make:middleware ?生成一个中间件
php artisan make:migration ?生成一个迁移文件
php artisan make:model ?生成一个Eloquent 模型类
php artisan make:provider ?生成一个服务提供商的类
php artisan make:request ?生成一个表单消息类
php artisan migrate:install ?创建一个迁移库文件
php artisan make:migration ?生成一个迁移文件
php artisan migrate:refresh ?复位并重新运行所有的迁移
php artisan migrate:reset ?回滚全部数据库迁移
php artisan migrate:rollback ?回滚最后一个数据库迁移
php artisan migrate:status显示列表的迁移
php artisan queue:failed列出全部失败的队列工作
php artisan queue:failed-table ?创建一个迁移的失败的队列数据库工作表
php artisan queue:flush清除全部失败的队列工作
php artisan queue:forget ?删除一个失败的队列工作
php artisan queue:listen ?监听一个确定的队列工作
php artisan queue:restart重启现在正在运行的所有队列工作
php artisan queue:retry重试一个失败的队列工作
php artisan queue:subscribe订阅URL,放到队列上
php artisan queue:table创建一个迁移的队列数据库工作表
php artisan queue:work进行下一个队列任务
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When this steroid is used, it undergoes a process referred to as aromatization, changing into estradiol, which is a type of estrogen. Some individuals are extra prone to experiencing estrogenic unwanted effects due to this conversion. First, the utilization of the AAS among physical schooling students is likely underestimated because self-reported health practices are weak to social desirability bias. Second, in the course of the ongoing COVID-19 epidemic, social distancing regulations prevented more correct precise practices. The endocrine system has a remarkable array of checks and balances that ensure the human body is at or close to homeostasis at any point in time. Interruption of 1 feedback system has been shown to produce changes in other hormone suggestions techniques through direct receptor modifications, in addition to through competition for common enzymes and metabolic pathways. Studies have shown that AASs bind to glucocorticoid, progesterone, and estrogen receptors and exert multiple effects. Discussions exist as to how the endogenous testosterone and spermatogenic functions of the testes are inhibited by means of testosterone and AASs. AAS use also ends in suppression of clotting factors II, V, VII, and X, in addition to a rise in prothrombin time. However, it remains to be decided whether or not therapeutic phlebotomy affects medical endpoints such as MACE and VTE or solely ‘treats’ a laboratory abnormality. The helpful effect of therapeutic phlebotomy on clinical outcomes in polycythemia vera patients (53) shouldn't immediately be assumed to hold true on this group of patients due to the differences in pathophysiology. Nonprescription doses are sometimes 10 to 100 instances greater than the doses healthcare providers prescribe to deal with medical circumstances. This is why the unwanted facet effects are usually more extreme than the unwanted effects of prescribed anabolic steroid use. The current examine demonstrates that injectable testosterone preparations, synthetic AAS, non-AAS hormone therapies, postcycle recovery agents, and non-AAS supplements are available and remarkably straightforward to buy on the Web and not using a prescription. Likewise, ample data is on the market on how to "cycle" and "stack" numerous AAS substances but little information is out there on the negative effects of AAS or nonsteroid alternate options. Second, some individuals might develop antagonistic effects from long-term AAS use, but the etiologic function of AAS in these cases may go unrecognized, both as a result of the clinician fails to elicit a history of AAS use, or as a end result of the affected person fails to reveal it. Data concerning miRNAs in human illnesses associated to AAS use/abuse may finally lead to establish serum or tissue biomarkers with anti-doping potential. In this regard, the necessity for cautious validation of diagnostic miRNA candidates in well-annotated toxicological studies is mandatory. The rapid progress in anti-doping applied sciences using miRNA primarily based strategies for the invention of drug-abuse, such as AAS use/abuse, might optimize new approaches based on present and emerging data. In the absence of medical context, interpretation of blood abnormalities can lead to inappropriate or unwarranted referrals to secondary care, stretching an already burdened healthcare system. Moreover, these sufferers could then be subject to pointless investigations, for instance, an intensive liver or pituitary display screen. These research administered most weekly doses of 500 mg, mg,80-82 and 1440 mg eighty three of testosterone or equivalent. A fifth blinded study84 administered testosterone 600 milligrams per week to thirteen men but did not provide data from psychological measures. Collectively, the four evaluable research evaluated 109 men; 5 (4.6%) developed hypomanic or manic syndromes throughout blinded AAS administration, whereas none confirmed such syndromes on placebo. In certainly one of these research,eighty three one of many 20 volunteers, a man with no prior psychiatric historical past, turned so aggressive throughout blinded AAS administration that he was placed in a seclusion room. In another examine,81 a beforehand asymptomatic man grew to become so aggressive on 600 milligrams per week of testosterone that he frightened people at his job and needed to be withdrawn from the examine for security. In the course of this latter research, the investigators also administered the Cherek Level Subtraction Aggression Paradigm85 to a subgroup of the research participants.86 In this protocol, the participant performed a "game" on a pc towards an unseen opponent. LDH, AST and ALT are expressed in skeletal muscle tissue, and their serum concentrations can remain elevated for a minimal of 7 days after intense muscular train such as weightlifting (110). Considering that the average training regimen of an AAS person entails no less than three to six periods per week of no less than one hour, this is bound to have an impact on these markers. Therefore, ideally, measurement ought to be performed after no less than 1 week of abstinence of exercise. GGT and bilirubin ranges in serum do not seem to extend in response to train (111). Nevertheless, even with medical therapy, a considerable proportion of patients can proceed to have subfertile semen parameters and finally require assisted replica (3). Steroid use to enhance power, athletic performance, or appearance is taken into account steroid abuse.[4] There are not any medical or therapeutic benefits to the excessive doses required to achieve these results, and the risks of adverse penalties are significant. According to Endocrine Society 2010 tips, testosterone levels should be measured midway between injections of testosterone enanthate or cypionate. Any dose and frequency changes ought to maintain the testosterone concentration between 400 and seven-hundred ng/dL. However, some specialists advocate checking the peak testosterone levels, that are best obtained 2 days after an IM injection once maintenance levels are reached. The goal is to keep the peak level within the center third of the traditional vary, keep away from the potential toxicity of supernormal testosterone ranges, and relieve the particular symptom of hypogonadism that justified its use initially. Dromostanolone is an artificial anabolic steroid with anti-estrogenic properties and is 5 times more potent than methyltestosterone, which is usually used illegally by bodybuilders to arrange for competition. First, as talked about, only the first 10 hits throughout the Google search have been evaluated. Whereas many sites were likely excluded by such criteria, the intent of the authors was to mimic the typical Internet user’s behavior, and previous data point out that Web users rarely search past the first page of search outcomes (Eysenbach & Kohler, 2002). Second, the analysis of the buying course of terminated simply before confirming the purchase, and, subsequently, it is unknown that if any of the websites would actually deliver the ordered merchandise.
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When used beneath medical supervision, steroids can assist within the recovery course of and assist athletes return to their sport more quickly. Steroids can offer benefits, notably for these with specific medical needs, but their misuse poses critical health dangers. It is essential for individuals contemplating their use to consult healthcare professionals and perceive both the potential advantages and dangers. Educating oneself about steroids can empower knowledgeable choices, whether or not it pertains to athletic performance or managing well being circumstances. There are several various varieties of performance-enhancing steroids, including testosterone, nandrolone, stanozolol, and oxandrolone, among others. These steroids are typically taken orally, injected, or applied topically within the form of gels or creams. With a modest calorie deficit food plan and common workouts, bodybuilders can sometimes retain their muscle dimension and strength when slicing without the addition of Dianabol. Thus, we don't see many compelling reasons to use methandrostenolone when chopping. You can see that some of the old bodybuilders who’ve come off steroids can shrink dramatically. However, a large proportion of this muscle loss may be attributed to them having stopped lifting weights. Nonetheless, 6 months later, when the mice had been subjected to energy training (this time without steroids), they grew by 30% in comparability with a control group that didn’t grow considerably. Thus, taking steroids is assumed to have a permanent effect on a user’s muscle myonuclei, serving to them to develop bigger later in life (naturally). By the top of this text, you ought to have a comprehensive understanding of the complexities surrounding the use of steroids in sports. The debate round steroids includes not only the physiological effects on athletes but in addition broader moral questions relating to equity, integrity, and the spirit of competition. The use of steroids in sports activities is a highly controversial problem that has sparked debates across the globe. Primobolan is a renowned anabolic steroid known for its varied advantages, including lean muscle mass improvement, elevated strength, enhanced athletic performance, and improved body composition. As with any steroid, it’s necessary to match Primobolan with different anabolic steroids to know its unique characteristics and advantages. The following comparative table highlights key aspects of Primobolan compared to other in style anabolic steroids. Anabolic steroids are synthetic variations of the male hormone testosterone. They have been initially developed for medical functions, similar to treating delayed puberty, muscle losing ailments, and sure kinds of anemia. In medication, Dianabol was additionally prescribed to deal with the elderly and those affected by severe burns, with both of these individuals prone to appreciable reductions in muscle mass. Dr. Ziegler noted that the Russian athletes had been experiencing androgenic unwanted effects in the course of the 1956 Olympics (in Australia) when he discovered they had been experiencing difficulty urinating. This was because of enlarged prostates caused by the high conversion from testosterone to DHT. Corticosteroids shortly lower inflammation by mimicking the results of cortisol. While they can be useful for acute or extreme persistent inflammatory circumstances, these medicines are also infamous for his or her adverse side effects over time. Nevertheless, taking steroids for other functions is illegal, in addition to taking steroids that are not prescribed to you for any underlying medical condition. Corticosteroids, however, are drugs used to assist treat a variety of acute and continual health conditions. This specific examine discovered that though the utilization of steroids carried no adverse side-effects, there was additionally no proof to indicate that the use of anabolic steroids improved the therapeutic of pressure ulcers. Correct testing for HGH in athletes is not as easy as detecting most anabolic steroids or other PEDs, and urine testing can not be used to detect HGH. A particular take a look at has been created to detect HGH in athletes, called the Human Development Hormone (hGH) Biomarkers Test, which focuses on detecting levels of IGF-1 and P-III-NP. You’ll also improve your threat of cardiovascular complications, as steroids can elevate your blood stress and contribute to cardiovascular disease. Sure, if you take prescription anabolic steroids beneath the supervision of your healthcare supplier for a medical purpose, anabolic steroids are usually secure. Nevertheless, if high dosages of steroids are used over the lengthy term, customers could expertise decreased cognitive efficiency, particularly in relation to visuospatial memory (4). As a results of such analysis, there are now links associating aggressive anabolic steroid use with dementia. There’s no way to guarantee you’ll avoid side effects or problems, however using corticosteroids exactly as your healthcare supplier prescribes them is the easiest way to reduce back your threat. There are a lot of other ways your provider might provide you with a steroid. They might apply it regionally, which means a targeted dose to a precise location in or on your body.
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Bodybuilding enthusiasts often turn to anabolic steroids to accelerate muscle growth and enhance physical performance. One of the most popular compounds in this category is Anavar, also known by its chemical name oxandrolone. Although it is marketed as a mild steroid with fewer side effects than many of its counterparts, it still carries significant risks that must be carefully considered before use. The following discussion will cover the benefits, side effects, recommended dosage ranges, and additional considerations for those who choose to incorporate Anavar into their training program. In addition, we will explore how this compound can contribute to fat loss, a key goal for many athletes during cutting phases. Anavar (Oxandrolone): Benefits, Side Effects, Dosage, and More Benefits Rapid lean muscle mass gains: Users report noticeable increases in muscle density without excessive water retention. Strength improvements: Even at low doses, Anavar can enhance maximal strength by 10‑20 percent over a few weeks. Reduced recovery time: The steroid helps mitigate protein breakdown during intense workouts, allowing for quicker regeneration of muscle tissue. Low androgenic activity: Compared to many other anabolic agents, oxandrolone has minimal masculinizing effects, making it a favored choice among female athletes and those concerned about virilization. Good oral bioavailability: Because the drug is taken by mouth, it bypasses liver first‑pass metabolism more effectively than some injectable steroids. Side Effects Liver strain: Even though Anavar is considered relatively mild for hepatic toxicity, prolonged use can still elevate liver enzymes and lead to jaundice or hepatitis in susceptible individuals. Hormonal disruption: The compound suppresses natural testosterone production; post-cycle therapy may be required to restore endocrine balance. Cardiovascular impact: Users may experience changes in lipid profiles—specifically lowered HDL cholesterol and elevated LDL levels—which can increase the risk of atherosclerosis over time. Skin reactions: Acne and oily skin are common, especially during higher dose cycles. Mood alterations: Some users report mood swings or increased aggression; these effects tend to be less pronounced than with stronger steroids but should not be ignored. Dosage The dosage of Anavar varies depending on the user’s experience level, training goals, and tolerance for side effects. Common regimens include: Beginner cycle (male): 20–30 mg per day for 6‑8 weeks. Intermediate male: 40–60 mg per day for 8‑10 weeks. Advanced male: 60–80 mg per day for 8‑12 weeks, though caution is advised as higher doses amplify risk factors. Female dosage ranges are typically half of those prescribed to males, with 5–15 mg per day being a common starting point for 4‑6 week cycles. Additional Considerations Cycle length: Prolonged use beyond 10 weeks increases the likelihood of adverse effects; many athletes limit Anavar to short bursts. Post-cycle therapy (PCT): To counteract testosterone suppression, individuals often incorporate selective estrogen receptor modulators or aromatase inhibitors after discontinuation. Monitoring: Regular blood work—including liver panels and lipid profiles—is essential for early detection of complications. Anavar (Oxandrolone): Benefits, Side Effects, Dosage, and More Benefits Lean muscle accretion without significant water retention, preserving a dry aesthetic that is highly desirable during cutting phases. Enhanced protein synthesis: The steroid stimulates ribosomal activity within cells, accelerating the build‑up of contractile proteins. Versatility in training modalities: Whether performing hypertrophy sets or high‑intensity interval work, Anavar can provide consistent support for muscle endurance and recovery. Side Effects Potential for estrogenic conversion remains low but not absent; mild gynecomastia may develop in a small subset of users with extreme sensitivity. Psychological changes such as increased competitiveness are reported; these are usually short‑lived once the cycle ends. Rare cases of hepatotoxicity can manifest as dark urine or abdominal pain, especially when combined with other oral steroids. Dosage For experienced users who have tolerated lower doses without significant issues, a typical advanced regimen might involve 70–90 mg per day for 10 weeks, split into two equal portions taken in the morning and late afternoon. Additional Considerations Pairing with natural compounds like creatine or beta‑hydroxy‑beta‑methylbutyrate can synergistically enhance strength gains while mitigating some side effects. It is advisable to cycle Anavar separately from other potent anabolic agents to reduce cumulative liver stress. Fat Loss Anavar’s unique pharmacological profile makes it a useful ally for individuals seeking fat loss while preserving muscle mass. Its androgenic properties activate hormone receptors in adipose tissue, which increases metabolic rate and enhances lipolysis—the breakdown of stored fats into usable energy. Because the drug does not cause significant water retention, users can maintain a lean appearance without the bloated look often associated with other steroids. In a typical cutting cycle, Anavar is combined with a caloric deficit, high‑intensity resistance training, and cardio sessions to maximize fat oxidation. The steroid’s ability to suppress testosterone production also helps prevent the body from shifting towards muscle preservation at the expense of fat loss; however, this suppression must be managed carefully through post‑cycle therapy. When using Anavar for fat loss, it is recommended that athletes start with a lower dose—around 20–30 mg per day—to evaluate tolerance. Over time, if no adverse effects arise, the dosage can be incrementally increased to 40–50 mg per day, maintaining a maximum cycle length of eight weeks. Regular body composition measurements (e.g., DEXA scans or skinfold calipers) should guide adjustments and confirm that fat mass is decreasing while lean tissue remains stable. In summary, Anavar offers a blend of muscle‑building benefits and fat‑loss support with relatively low androgenic side effects compared to many other anabolic steroids. Nonetheless, its use carries significant health risks that necessitate careful dosing, vigilant monitoring, and comprehensive post‑cycle care. Athletes who weigh the pros and cons and adopt responsible usage protocols can harness Anavar’s advantages while minimizing potential harm.
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